Publication | Closed Access
Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer's Disease
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Citations
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References
2002
Year
Neurochemical BiomarkersPharmacotherapyChemical BiologyAche Active SitePharmaceutical ChemistryMolecular PharmacologyMedicinal ChemistryAlzheimer's DiseaseHighly Efficient AcetylcholinesteraseNeurochemistryInhibitory ActivityBiochemistryDual InhibitorsMechanism Of ActionPharmacological AgentNeuropharmacologyDrug DevelopmentPharmacologyNatural SciencesRational Drug DesignNeuroscienceMedicineDrug Discovery
Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. Both compounds showed potent inhibitory activities against AChE and SERT. [structure: see text]
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