Design, synthesis and structure–Activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease

Samantha Rogers, Martin R. Farlow, Rachelle S. Doody et al. · Neurology · 1998 · 1.6K citations

Medicine, Pharmacotherapy, Psychiatry +17

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

William K. Summers, Lawrence V. Majovski, Gary M. Marsh et al. · New England Journal of Medicine · 1986 · 1.2K citations

Medicine, Neurology, Pharmacology +15

The occurrence of depressive symptoms in the preclinical phase of AD

Anna‐Karin Berger, Laura Fratiglioni, Yvonne Forsell et al. · Neurology · 1999 · 232 citations

Medicine, Psychiatry, Psychology +12

Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Sertraline in the Treatment of Depression Complicating Alzheimer’s Disease: Initial Results From the Depression in Alzheimer’s Disease Study

Constantine G. Lyketsos, Jeannie‐Marie E. Sheppard, Cynthia D. Steele et al. · American Journal of Psychiatry · 2000 · 213 citations

Medicine, Pharmacology, Psychiatry +17