James J. Powers

Discovery of 4-((2 <i>S</i> ,4 <i>S</i> )-4-Ethoxy-1-((5-methoxy-7-methyl-1 <i>H</i> -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki et al. · Journal of Medicinal Chemistry · 2020 · 57 citations

The Discovery of <i>N</i>-(1-Methyl-5-(trifluoromethyl)-1<i>H</i>-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1<i>H</i>-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

Christopher M. Adams, Karen Anderson, Gerald D. Artman et al. · Journal of Medicinal Chemistry · 2018 · 36 citations · Full text

Ocular Disease, Choroidal Neovascularization, Pharmacotherapy +17

Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

Erik L. Meredith, Nello Mainolfi, Stephen Poor et al. · Journal of Medicinal Chemistry · 2015 · 29 citations · Full text

Translational Medicine, Ocular Disease, Ophthalmology +13

A Reliable Synthesis of 3-Amino-5-Alkyl and 5-Amino-3-Alkyl Isoxazoles

Nello Mainolfi, Leland Johnson, James J. Powers et al. · Synthesis · 2012 · 21 citations

Engineering, Reliable Procedure, Organic Chemistry +9

Synthesis of chromanyl and dihydrobenzofuranyl piperazines

David A. Favor, Douglas S. Johnson, James J. Powers et al. · Tetrahedron Letters · 2007 · 18 citations

Organic Chemistry, Heterocyclic, Dihydrobenzofuranyl Piperazines