2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura, +13

Journal of Medicinal Chemistry

-5-Methyl-1,3,4-oxadiazole DerivativesGood Brain PermeabilityPharmacotherapyPharmaceutical ChemistrySocial Sciences +17

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(<i>S </i>)‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno, +7

Journal of Neurochemistry

Amyloid βBrain PenetrationNeurochemical BiomarkersSynaptic SignalingSocial Sciences +26

Synthesis of Novel 4,1-Benzoxazepine Derivatives as Squalene Synthase Inhibitors and Their Inhibition of Cholesterol Synthesis

Takashi Miki, Masakuni Kori, Hiroshi Mabuchi, +5

Journal of Medicinal Chemistry

Total Synthesis of Rapamycin

Steven V. Ley, Miles N. Tackett, Matthew L. Maddess, +20

Chemistry - A European Journal

Syntheses of fused heterocyclic compounds and their inhibitory activities for squalene synthase

Takashi Miki, Masakuni Kori, Akira Fujishima, +5

Bioorganic & Medicinal Chemistry

EngineeringHeterocyclicBiochemistrySqualene SynthaseNatural Sciences +8

Discovery of Novel, Highly Potent, and Selective Quinazoline-2-carboxamide-Based Matrix Metalloproteinase (MMP)-13 Inhibitors without a Zinc Binding Group Using a Structure-Based Design Approach

Hiroshi Nara, Kenjiro Sato, Takako Naito, +9

Journal of Medicinal Chemistry

Zinc Binding GroupChemical BiologyPharmaceutical ChemistryMusculoskeletal ResearchBioavailable Mmp-13 Inhibitors +18

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach

Hiroshi Nara, Akira Kaieda, Kenjiro Sato, +10

Journal of Medicinal Chemistry

Discovery of the First Potent and Orally Available Agonist of the Orphan G-Protein-Coupled Receptor 52

Masaki Setoh, Naoki Ishii, Mitsunori Kono, +9

Journal of Medicinal Chemistry

PsychopharmacologyPharmacotherapySocial SciencesGpr52 AgonistsMolecular Pharmacology +17

Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: Highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site

Hiroshi Nara, Kenjiro Sato, Takako Naito, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAvailable Mmp-13 InhibitorsBiochemistryCarboxybenzene GroupMedicine +9

Improvement of the process in the synthesis of 2-oxazolidinones from 2-amino alcohols and carbon dioxide by use of triphenylstibine oxide as catalyst

Haruo Matsuda, Akio Baba, Ryôki Nomura, +2

Industrial & Engineering Chemistry Product Research and Development

Carbon Dioxide2-Amino AlcoholsEngineeringAltmetric Attention ScoreOrganic Chemistry +9