Leen Kwanten

Molecular mechanism of respiratory syncytial virus fusion inhibitors

Michael B. Battles, Johannes P. M. Langedijk, Polina Furmanova-Hollenstein et al. · Nature Chemical Biology · 2015 · 171 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +14

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor

Dirk Roymans, Sarhad Alnajjar, Michael B. Battles et al. · Nature Communications · 2017 · 97 citations · Full text

Life Sciences, Infectious Diseases, Pharmacology +17

Which Compound to Select in Lead Optimization? Prospectively Validated Proteochemometric Models Guide Preclinical Development

Gerard J. P. van Westen, Jörg K. Wegner, Peggy Geluykens et al. · PLoS ONE · 2011 · 55 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +16

Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1<i>H</i>-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2<i>H</i>-imidazo[4,5-<i>c</i>]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus

Sandrine Vendeville, Abdellah Tahri, Lili Hu et al. · Journal of Medicinal Chemistry · 2020 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Evaluation of Antiviral Efficacy Against Human Respiratory Syncytial Virus Using Cotton Rat and Mouse Models

Joke Van Den Berg, Leen Kwanten, Dirk Roymans · Methods in molecular biology · 2013 · 18 citations

Veterinary Medicine, Infectious Diseases, Pharmacotherapy +16