Concepedia

Michael Grimwood

MG

7

Publications

584

Citations

7

H-Index

2009

Active since

Affiliations

Xenon Pharmaceuticals (Canada)(Current)

Shanghai Zhangjiang Laboratory

Michael Grimwood is an author at Xenon Pharmaceuticals (Canada) specializing in drug discovery, natural sciences, and medicine.

Top concepts

Publications per year

2009–2019

7

Publications

7

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

Shivani Ahuja, Susmith Mukund, Lunbin Deng et al. · Science · 2015 · 322 citations · Full text

, , +18

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain

Girish Bankar, Samuel J. Goodchild, Sarah Howard et al. · Cell Reports · 2018 · 75 citations · Full text

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of Na<sub>V</sub>1.7 with Efficacy in Rodent Pain Models

Thilo Focken, Shifeng Liu, Navjot Chahal et al. · ACS Medicinal Chemistry Letters · 2016 · 71 citations · Full text

, , +19

Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na <sub>V</sub> ) 1.7 with Potent Analgesic Activity

Shaoyi Sun, Qi Jia, Alla Zenova et al. · Journal of Medicinal Chemistry · 2018 · 34 citations · Full text

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na<sub>V</sub>1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy

Thilo Focken, Kristen Burford, Michael Grimwood et al. · Journal of Medicinal Chemistry · 2019 · 31 citations · Full text

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