Michael Grimwood - Concepedia

Author

Michael Grimwood

Xenon Pharmaceuticals (Canada)

Also Known As

Grimwood, Michael E, Grimwood, Michael E., Michael E. Grimwood, Michael Grimwood

Publications

601

Citations

H-Index

Concepts

All Affiliations

Xenon Pharmaceuticals (Canada)Shanghai Zhangjiang Laboratory

About

Michael Grimwood is an author at Xenon Pharmaceuticals (Canada) specializing in drug discovery, natural sciences, and medicine.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	2	2	393
2	Natural Sciences	2	2	343
3	Engineering	1	1	21
4	Health Sciences	1	1	71
5	Biochemistry	1	1	71

Michael Grimwood

Publications

584

Citations

H-Index

Page 1

	Year	Citations
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist Shivani Ahuja, Susmith Mukund, Lunbin Deng, Science Voltage-gated SodiumMolecular BiologyMolecular PharmacologyIsoform SelectivityInhibitory Activity	2015	322
Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain Girish Bankar, Samuel J. Goodchild, Sarah Howard, Cell Reports	2018	75
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of Na<sub>V</sub>1.7 with Efficacy in Rodent Pain Models Thilo Focken, Shifeng Liu, Navjot Chahal, ACS Medicinal Chemistry Letters Pain MedicineMolecular PainPharmacotherapyExperimental PharmacologyRodent Pain Models	2016	71
Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na <sub>V</sub> ) 1.7 with Potent Analgesic Activity Shaoyi Sun, Qi Jia, Alla Zenova, Journal of Medicinal Chemistry	2018	34
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na<sub>V</sub>1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy Thilo Focken, Kristen Burford, Michael Grimwood, Journal of Medicinal Chemistry	2019	31
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of<i>N</i>-([1,2,4]Triazolo[4,3-<i>a</i>]pyridin-3-yl)methane-sulfonamides as Potent and Selective<i>h</i>Na<sub>V</sub>1.7 Inhibitors for the Treatment of Pain Thilo Focken, Sultan Chowdhury, Alla Zenova, Journal of Medicinal Chemistry	2018	30
Synthesis of macrocyclic scaffolds suitable for diversity-oriented synthesis of macrolides Michael Grimwood, Henrik C. Hansen Tetrahedron Combinatorial ChemistryDiversity Oriented SynthesisEngineeringHeterocyclicNatural Sciences	2009	21

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