Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats

Girish Bankar, Pawan G. Nayak, Punit Bansal, +4

Journal of Ethnopharmacology

HypertensionMedicineAntihypertensive TherapyPhysiologyEndothelial Dysfunction +6

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain

Girish Bankar, Samuel J. Goodchild, Sarah Howard, +24

Cell Reports

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of Na_V1.7 with Efficacy in Rodent Pain Models

Thilo Focken, Shifeng Liu, Navjot Chahal, +23

ACS Medicinal Chemistry Letters

Pain MedicineMolecular PainPharmacotherapyExperimental PharmacologyRodent Pain Models +17

Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ₂

H. S. Soliman, Anthony Gador, Yi‐Hsuan Lu, +3

American Journal of Physiology-Heart and Circulatory Physiology

Cardiac MuscleRedox BiologyInsulin SignalingPositive Feedback LoopOxidative Stress +19

Vasorelaxant effect in rat aortic rings through calcium channel blockage: A preliminary in vitro assessment of a 1,3,4-oxadiazole derivative

Girish Bankar, Krishnadas Nandakumar, Pawan G. Nayak, +3

Chemico-Biological Interactions

MechanobiologyVasorelaxant EffectMedicineVascular PharmacologyPhysiology +6

Discovery of Acyl-sulfonamide Na_v1.7 Inhibitors GDC-0276 and GDC-0310

Brian S. Safina, Steven J. McKerrall, Shaoyi Sun, +44

Journal of Medicinal Chemistry

Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction

H. S. Soliman, Vongai Nyamandi, Marysol García-Patiño, +5

American Journal of Physiology-Heart and Circulatory Physiology

Heart FailureMetabolic DisorderCardiac Insulin ResistanceMetabolic RemodelingCardiovascular Function +21

Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na _V ) 1.7 with Potent Analgesic Activity

Shaoyi Sun, Qi Jia, Alla Zenova, +35

Journal of Medicinal Chemistry

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of<i>N</i>-([1,2,4]Triazolo[4,3-<i>a</i>]pyridin-3-yl)methane-sulfonamides as Potent and Selective<i>h</i>Na_V1.7 Inhibitors for the Treatment of Pain

Thilo Focken, Sultan Chowdhury, Alla Zenova, +37

Journal of Medicinal Chemistry

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Na_v1.7 Inhibitors for the Treatment of Chronic Pain

Steven J. McKerrall, Teresa T. Nguyen, Kwong Wah Lai, +29

Journal of Medicinal Chemistry