Concepedia

Thilo Focken

TF

16

Publications

1K

Citations

16

H-Index

2001

Active since

Affiliations

Xenon Pharmaceuticals (Canada)(Current)

Université de Montréal

Shanghai Zhangjiang Laboratory

RWTH Aachen University

Thilo Focken is an author at Xenon Pharmaceuticals (Canada) specializing in engineering, chemistry, and organic chemistry.

Top concepts

ChemistryEngineeringOrganic ChemistryBiomolecular EngineeringPharmacologyMedicineCatalysisDrug DiscoveryNatural SciencesBiochemistry

Publications per year

2001–2024

16

Publications

16

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

Shivani Ahuja, Susmith Mukund, Lunbin Deng et al. · Science · 2015 · 322 citations · Full text

Voltage-gated Sodium, Molecular Biology, Molecular Pharmacology +18

Synthesis of iridium complexes with new planar chiral chelating phosphinyl-imidazolylidene ligands and their application in asymmetric hydrogenation

Thilo Focken, Gerhard Raabe, Carsten Bolm · Tetrahedron Asymmetry · 2004 · 115 citations

Inorganic Chemistry, Chemical Engineering, Engineering +8

Synthesis of iridium complexes with novel planar chiral chelating imidazolylidene ligands

Carsten Bolm, Thilo Focken, Gerhard Raabe · Tetrahedron Asymmetry · 2003 · 95 citations

Inorganic Chemistry, Engineering, Iridium Complexes +6

Stereoselective Synthesis of Pyridinones: Application to the Synthesis of (−)-Barrenazines

Thilo Focken, André B. Charette · Organic Letters · 2006 · 86 citations

Diversity Oriented Synthesis, Bioorganic Chemistry, Derivatives +13

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of Na<sub>V</sub>1.7 with Efficacy in Rodent Pain Models

Thilo Focken, Shifeng Liu, Navjot Chahal et al. · ACS Medicinal Chemistry Letters · 2016 · 71 citations · Full text

Pain Medicine, Molecular Pain, Pharmacotherapy +19

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