Elizabeth Blackwood

USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé et al. · Nature · 2017 · 332 citations · Full text

Molecular Docking, Ubiquitin Binding, Drug Target +7

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

Elaine E. Storm, Steffen Durinck, Felipe de Sousa e Melo et al. · Nature · 2015 · 248 citations

Stem-cell Function, Cancer Research, Signaling Pathway +13

Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases

Guanglei Zhuang, Kebing Yu, Zhaoshi Jiang et al. · Science Signaling · 2013 · 82 citations

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p <i>K</i> _a Polar Moiety

Chudi Ndubaku, James J. Crawford, Joy Drobnick et al. · ACS Medicinal Chemistry Letters · 2015 · 81 citations · Full text

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Joachim Rudolph, Lesley Murray, Chudi Ndubaku et al. · Journal of Medicinal Chemistry · 2016 · 74 citations · Full text

Cardiovascular Pharmacology, Pharmacotherapy, Cardiovascular Toxicity +18