Julia Shin

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial

Aaron Winkler, Weiyong Sun, Saurav De et al. · Arthritis & Rheumatology · 2021 · 90 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4

L. Nathan Tumey, Diane H. Boschelli, Niala Bhagirath et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 38 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

Jiang Wu, Julia Shin, Cara Williams et al. · MedChemComm · 2014 · 11 citations

Life Sciences, Biochemistry, Molecular Biology +17