Aoli Wang

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Hongbin He, Hua Jiang, Yun Chen et al. · Nature Communications · 2018 · 746 citations · Full text

Inflammation, Covalent Nlrp3 Inhibitor, Nlrp3 Inflammasome Assembly +14

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Hua Jiang, Hongbin He, Yun Chen et al. · The Journal of Experimental Medicine · 2017 · 694 citations · Full text

Direct Nlrp3 Inhibitor, Immunology, Inflammation +21

Variation of gut microbiota caused by an imbalance diet is detrimental to bugs' survival

Jing Luo, Yanxia Cheng, Libin Guo et al. · The Science of The Total Environment · 2021 · 78 citations

Nutrition, Dysbiosis, Host-microbe Interactions +16

Discovery of N -(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC

Yongfei Chen, Jiaxin Wu, Aoli Wang et al. · European Journal of Medicinal Chemistry · 2017 · 58 citations · Full text

Drug Target, Medicine, Rational Drug Design +7

Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor

Beilei Wang, Jiaxin Wu, Yun Wu et al. · European Journal of Medicinal Chemistry · 2018 · 50 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +8