Heike I. Krupka

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

Dean R. Artis, Jack J. Lin, Chao Zhang et al. · Proceedings of the National Academy of Sciences · 2008 · 146 citations · Full text

Metabolic Syndrome, Medicinal Chemistry, Biochemistry +15

The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1

Weiru Wang, Chao Zhang, Adhirai Marimuthu et al. · Proceedings of the National Academy of Sciences · 2005 · 142 citations

Molecular Biology, Transcriptional Regulation, Regulatory Ligands +20

Crystal Structure of the Mycobacterium tuberculosis dUTPase: Insights into the Catalytic Mechanism

Sum Chan, Brent W. Segelke, Timothy Lekin et al. · Journal of Molecular Biology · 2004 · 95 citations

Crystal Structure, Biochemistry, Medicine +9

A phase 1, dose-escalation study of PF-06664178, an anti-Trop-2/Aur0101 antibody-drug conjugate in patients with advanced or metastatic solid tumors

Gentry Teng King, Keith D. Eaton, Brandon Beagle et al. · Investigational New Drugs · 2018 · 86 citations · Full text

Dose-escalation Study, Anti-trop-2/aur0101 Antibody-drug Conjugate, Medicine +7

Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase

Weiru Wang, Adhirai Marimuthu, James Tsai et al. · Proceedings of the National Academy of Sciences · 2006 · 84 citations · Full text

Crystal Structure, Structural Characterization, Protein Assembly +18