A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

Kam Y. J. Zhang, G.L. Card, Yoshihisa Suzuki, +11

Molecular Cell

Signal TransductionBiochemistryG Protein-coupled ReceptorNatural SciencesGlutamine Switch Mechanism +2

Inhibitor hijacking of Akt activation

Tatsuya Okuzumi, Dorothea Fiedler, Chao Zhang, +4

Nature Chemical Biology

Signal TransductionInhibitor HijackingMedicineMechanism Of ActionPharmacotherapy +4

MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer

Lin Zheng, Yu‐Qin Zhang, Yan Liu, +7

Journal of Translational Medicine

CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling

Zhiqiang Zhao, Dapeng Hao, Li Wang, +8

Oncogene

Breast OncologyOncologyMedicineTgf-β SignalingPathology +7

The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1

Weiru Wang, Chao Zhang, Adhirai Marimuthu, +10

Proceedings of the National Academy of Sciences

Molecular BiologyTranscriptional RegulationRegulatory LigandsSignaling PathwaySex Determination +18

Renal plasticity revealed through reversal of polycystic kidney disease in mice

Ke Dong, Chao Zhang, Xin Tian, +4

Nature Genetics

GlomerulonephritisUrologyRenal DiseaseRenal FunctionMedicine +8

Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma

Shanshan Wang, Wei Jiang, Xiangmei Chen, +7

Journal of Hepatology

Tumor BiologyHepatologyAlpha-fetoprotein ActsHuman Hepatocellular CarcinomaLiver Physiology +10

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling

Qing Yin, Tao Han, Bin Fang, +13

Nature Communications

Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.

Qi-Wen Fan, Kimberly Musa Specht, Chao Zhang, +3

PubMed

Combinatorial EfficacyAkt KinaseGliomaTumor BiologySignaling Pathway +16

<i>Retracted</i> : MicroRNA‐126 Inhibits Proliferation, Migration, Invasion, and EMT in Osteosarcoma by Targeting ZEB1

Rui Jiang, Chao Zhang, Guangyao Liu, +2

Journal of Cellular Biochemistry