BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

Eleni D. Lagadinou, Alexander Sach, Kevin P. Callahan, +11

Cell stem cell

Hematological MalignancyCancer ResearchMedicineMixed-phenotype Acute LeukemiaCell Death +6

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

Daniel A. Pollyea, Brett M. Stevens, Courtney L. Jones, +14

Nature Medicine

Hematological MalignancyMedicineAcute Myeloid LeukemiaStem CellsPharmacology +7

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

Haobin Ye, Biniam Adane, Nabilah Khan, +12

Cell stem cell

MedicineStem Cell MobilizationBiological MicroenvironmentsMetabolic AdaptationAdipose Tissue Niche +9

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

Shanshan Pei, Daniel A. Pollyea, Annika Gustafson, +29

Cancer Discovery

Mixed-phenotype Acute LeukemiaImmunologyPharmacotherapyImmunotherapyDrug Resistance +17

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

Shanshan Pei, Mohammad Minhajuddin, Biniam Adane, +15

Cell stem cell

Cell AutophagyMitophagyDevelopmental BiologyCell RegulationMedicine +5

Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells

Courtney L. Jones, Brett M. Stevens, Daniel A. Pollyea, +19

Cell stem cell

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaStem CellsHematology +5

Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells

Shanshan Pei, Mohammad Minhajuddin, Kevin P. Callahan, +18

Journal of Biological Chemistry

Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats

Mohammad Minhajuddin, Zafarul H. Beg, Jahangir Iqbal

Food and Chemical Toxicology

Food ChemistryRice Bran OilMedicineNutraceutical IngredientTocotrienol Rich Fraction +4

The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation

Maria L. Amaya, Anagha Inguva Sheth, Shanshan Pei, +12

Blood

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells

Haobin Ye, Biniam Adane, Nabilah Khan, +14

Cancer Cell

Developmental BiologyMetabolic ReprogrammingLeukemia CellsMetabolic RegulationSystemic Glucose Metabolism +7