BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

Eleni D. Lagadinou, Alexander Sach, Kevin P. Callahan, +11

Cell stem cell

Hematological MalignancyCancer ResearchMedicineMixed-phenotype Acute LeukemiaCell Death +6

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

Daniel A. Pollyea, Brett M. Stevens, Courtney L. Jones, +14

Nature Medicine

Hematological MalignancyMedicineAcute Myeloid LeukemiaStem CellsPharmacology +7

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, +13

Cancer Cell

Hematological MalignancyBiochemistryMedicineMixed-phenotype Acute LeukemiaPharmacology +3

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

Haobin Ye, Biniam Adane, Nabilah Khan, +12

Cell stem cell

MedicineStem Cell MobilizationBiological MicroenvironmentsMetabolic AdaptationAdipose Tissue Niche +9

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

Shanshan Pei, Daniel A. Pollyea, Annika Gustafson, +29

Cancer Discovery

Mixed-phenotype Acute LeukemiaImmunologyPharmacotherapyImmunotherapyDrug Resistance +17

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

Shanshan Pei, Mohammad Minhajuddin, Biniam Adane, +15

Cell stem cell

Cell AutophagyMitophagyDevelopmental BiologyCell RegulationMedicine +5

Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells

Brett M. Stevens, Courtney L. Jones, Daniel A. Pollyea, +13

Nature Cancer

Hematological MalignancyMixed-phenotype Acute LeukemiaHematologyImmunologyMetabolism Underlies +4

Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells

Courtney L. Jones, Brett M. Stevens, Daniel A. Pollyea, +19

Cell stem cell

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaStem CellsHematology +5

Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells

Shanshan Pei, Mohammad Minhajuddin, Kevin P. Callahan, +18

Journal of Biological Chemistry

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

Hiba Ahmad Zahreddine, Biljana Culjkovic‐Kraljacic, Sarit Assouline, +15

Nature

MedicineGlycobiologyPharmacologyCell BiologyDrug Discovery +2