Mutations in the Epidermal Growth Factor Receptor and in KRAS Are Predictive and Prognostic Indicators in Patients With Non–Small-Cell Lung Cancer Treated With Chemotherapy Alone and in Combination With Erlotinib

David A. Eberhard, Bruce E. Johnson, Lukas C. Amler, +16

Journal of Clinical Oncology

A paracrine requirement for hedgehog signalling in cancer

Robert L. Yauch, Stephen E. Gould, Suzie J. Scales, +12

Nature

Cancer ResearchSignaling PathwayMedicineParacrine RequirementTumor Suppressor +4

<i>Smoothened</i> Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

Robert L. Yauch, Gerrit J.P. Dijkgraaf, Bruno Alicke, +15

Science

Health SciencesGliomaGeneticsSame Amino AcidHedgehog Pathway Inhibitor +12

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL

Klaus W. Wagner, Elizabeth A. Punnoose, Thomas Januario, +13

Nature Medicine

Cancer ResearchG Protein-coupled ReceptorMedicineApoptosisCell Death +7

Epithelial versus Mesenchymal Phenotype Determines <i>In vitro</i> Sensitivity and Predicts Clinical Activity of Erlotinib in Lung Cancer Patients

Robert L. Yauch, Thomas Januario, David A. Eberhard, +11

Clinical Cancer Research

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

Hayley J. Sharpe, Grégoire Pau, Gerrit J.P. Dijkgraaf, +17

Cancer Cell

Radiation OncologyOncologySkin CancerTumor HeterogeneityMedicine +10

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Gerrit J.P. Dijkgraaf, Bruno Alicke, Lasse Weinmann, +11

Cancer Research

Molecular BiologyGliomaSmall Molecule InhibitionTumor BiologyDrug Resistance +16

TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer

Susanna Stinson, Mark R. Lackner, Alex Adai, +17

Science Signaling

Tumor BiologySystems BiologyBreast OncologyMir-221/222 PromotesTrps1 Targeting +11

Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Sharmila Makhija, Lukas C. Amler, D. Glenn, +10

Journal of Clinical Oncology

Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients

Tharu M. Fernando, Robert Piskol, Russell Bainer, +10

Nature Communications