Nathan R. Kett

Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation

B. Wesley Trotter, Kausik K. Nanda, Nathan R. Kett et al. · Journal of Medicinal Chemistry · 2006 · 97 citations · Full text

Medicinal Chemistry, Oral Bioavailability, Pharmaceutical Science +14

Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe

Eric Delpire, Aleksandra Baranczak, Alex G. Waterson et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 92 citations · Full text

Molecular Pharmacology, Molecular Physiology, Biochemistry +7

Discovery of the First M₅-Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (<i>S</i>)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1<i>H</i>-imidazo[2,1-<i>a</i>]isoindol-5(9b<i>H</i>)-one (ML375)

Patrick R. Gentry, Masaya Kokubo, Thomas M. Bridges et al. · Journal of Medicinal Chemistry · 2013 · 72 citations · Full text

Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy

B. Wesley Trotter, Kausik K. Nanda, Christopher S. Burgey et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 56 citations · Full text

Health Sciences, Functional Selectivity, Medicine +12

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

Scott T. Harrison, Michael S. Poslusney, James Mulhearn et al. · ACS Medicinal Chemistry Letters · 2015 · 44 citations · Full text