Concepedia

Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy

B. Wesley Trotter, Kausik K. Nanda, Christopher S. Burgey, Craig M. Potteiger, James Z. Deng, Ahren I. Green, John C. Hartnett, Nathan R. Kett, Zhicai Wu, Darrell A. Henze,

Bioorganic & Medicinal Chemistry Letters · 2011 · 59 citations · 11 references

DOIFull text

Open access

Concepts

References

11

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn

S. Boyce, A. C. Wyatt, J.K. Webb et al. · Neuropharmacology · 1999 · 338 citations

, , +17

Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics

Yukinori Nagakura, Masamichí Okada, Atsuyuki Kohara et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 179 citations

, , +12

Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration

Xingrong Liu, Bill J. Smith, Cuiping Chen et al. · Drug Metabolism and Disposition · 2006 · 161 citations

, , +17

Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB<sub>2</sub> Cannabinoid Receptor Activity

Jennifer M. Frost, Michael J. Dart, Karin Tietje et al. · Journal of Medicinal Chemistry · 2009 · 139 citations · Full text

, , +12

<i>In vitro</i>and<i>in vivo</i>characterization of A‐796260: a selective cannabinoid CB<sub>2</sub>receptor agonist exhibiting analgesic activity in rodent pain models

B. B. Yao, Gin C. Hsieh, Jennifer M. Frost et al. · British Journal of Pharmacology · 2007 · 136 citations · Full text

, , +17