Chinchu Johny

Synthesis and Bioactivity of β-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-<scp>d</scp>-xylulose-5-phosphate Reductoisomerase

René Chofor, Sanjeewani Sooriyaarachchi, Martijn Risseeuw et al. · Journal of Medicinal Chemistry · 2015 · 42 citations · Full text

Life Sciences, Medicinal Chemistry, Microbiology +14

Structure–Activity Relationships of the MEPicides: <i>N</i>-Acyl and <i>O</i>-Linked Analogs of FR900098 as Inhibitors of Dxr from <i>Mycobacterium tuberculosis</i> and <i>Yersinia pestis</i>

Géraldine San Jose, Emily R. Jackson, Amanda Haymond et al. · ACS Infectious Diseases · 2016 · 31 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Design of potential bisubstrate inhibitors against Mycobacterium tuberculosis (Mtb) 1-deoxy-d-xylulose 5-phosphate reductoisomerase (Dxr)—evidence of a novel binding mode

Géraldine San Jose, Emily R. Jackson, Eugene Uh et al. · MedChemComm · 2013 · 30 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs

Emily R. Jackson, Géraldine San Jose, Robert C. Brothers et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase)

Amanda Haymond, Chinchu Johny, Tyrone Dowdy et al. · PLoS ONE · 2014 · 20 citations · Full text

Life Sciences, Biochemistry, Drug Discovery +13