Julie Cianfrogna

THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Angela C. Doran, R. Scott Obach, Bill J. Smith et al. · Drug Metabolism and Disposition · 2004 · 440 citations

Medicine, Pharmacokinetics, Pharmacology +16

Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding

Xingrong Liu, Bill J. Smith, Cuiping Chen et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 184 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

An Inhibitor of Casein Kinase Iϵ Induces Phase Delays in Circadian Rhythms under Free-Running and Entrained Conditions

Lori L. Badura, Terri A. Swanson, Wendy O. Adamowicz et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 176 citations

Life Sciences, Biochemistry, Pharmacology +17

Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration

Xingrong Liu, Bill J. Smith, Cuiping Chen et al. · Drug Metabolism and Disposition · 2006 · 161 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Discovery of Two Clinical Histamine H ₃ Receptor Antagonists: <i>trans</i> - <i>N</i> -Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and <i>trans</i> -3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]- <i>N</i> -(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

Travis T. Wager, Betty Pettersen, Anne W. Schmidt et al. · Journal of Medicinal Chemistry · 2011 · 108 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16