Brian D. Hamman

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

Daniel P. Bondeson, Blake E. Smith, George M. Burslem et al. · Cell chemical biology · 2017 · 867 citations · Full text

Protac Design, Selective Degradation, Biomolecular Engineering +1

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

Blake E. Smith, Stephen L. Wang, Saul Jaime‐Figueroa et al. · Nature Communications · 2019 · 502 citations · Full text

BiP Maintains the Permeability Barrier of the ER Membrane by Sealing the Lumenal End of the Translocon Pore before and Early in Translocation

Brian D. Hamman, Linda M. Hendershot, Arthur E. Johnson · Cell · 1998 · 424 citations · Full text

Membrane Formation, Membrane Biophysics, Signal Transduction +11

Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming Toxin <i>Clostridium perfringens</i> Perfringolysin O:  An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy

Laura A. Shepard, Alejandro P. Heuck, Brian D. Hamman et al. · Biochemistry · 1998 · 317 citations

Proteinlipid Interaction, Toxinology, Analytical Ultracentrifugation +17

The Aqueous Pore through the Translocon Has a Diameter of 40–60 Å during Cotranslational Protein Translocation at the ER Membrane

Brian D. Hamman, Jui‐Chang Chen, Edward E Johnson et al. · Cell · 1997 · 278 citations · Full text

Protein Secretion, Biochemistry, Aqueous Pore +12