Dan Chen

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Daniel Martinez Molina, Rozbeh Jafari, Marina Ignatushchenko et al. · Science · 2013 · 2.2K citations

Medicine, Oncology, Pharmacology +17

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

Jerzy M. Dziekan, Han Yu, Dan Chen et al. · Science Translational Medicine · 2019 · 231 citations

Life Sciences, Biochemistry, Pharmacology +16

The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis

Margherita Bertuzzi, Markus Schrettl, Laura Alcázar‐Fuoli et al. · PLoS Pathogens · 2014 · 176 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Helena Almqvist, Hanna Axelsson, Rozbeh Jafari et al. · Nature Communications · 2016 · 164 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling

Xingsheng Ren, Ying Tong, Li Ling et al. · Cellular Physiology and Biochemistry · 2017 · 107 citations · Full text

Life Sciences, Cardiology, Pharmacology +14