Charles E. Grimshaw

The promise and peril of chemical probes

C.H. Arrowsmith, James E. Audia, Christopher P. Austin et al. · Nature Chemical Biology · 2015 · 850 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +12

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

Jerome C. Bressi, Andy Jennings, R.J. Skene et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 254 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +9

Tyrosine-48 Is the Proton Donor and Histidine-110 Directs Substrate Stereochemical Selectivity in the Reduction Reaction of Human Aldose Reductase: Enzyme Kinetics and Crystal Structure of the Y48H Mutant Enzyme

Kurt M. Bohren, Charles E. Grimshaw, Chung Jeng Lai et al. · Biochemistry · 1994 · 170 citations

Life Sciences, Biochemistry, Molecular Biology +14

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

Kazuhide Nakayama, Magdalena M. Szewczyk, Carlo dela Seña et al. · Oncotarget · 2018 · 144 citations · Full text

Medicine, Oncology, Pharmacology +10

Mechanism of Human Aldehyde Reductase: Characterization of the Active Site Pocket

Oleg A. Barski, Kenneth H. Gabbay, Charles E. Grimshaw et al. · Biochemistry · 1995 · 121 citations

Life Sciences, Biochemistry, Molecular Biology +13