Marcel Muelbaier

Design of amidobenzimidazole STING receptor agonists with systemic activity

Joshi M. Ramanjulu, G. Scott Pesiridis, Jingsong Yang et al. · Nature · 2018 · 803 citations

Systemic Activity, Medicine, Mechanism Of Action +4

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

Isabelle Becher, Thilo Werner, Carola Doce et al. · Nature Chemical Biology · 2016 · 250 citations

Biosynthesis, Engineering, Biochemistry +9

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

Mikhail M. Savitski, Nico Zinn, Maria Faelth-Savitski et al. · Cell · 2018 · 222 citations · Full text

PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding

Christopher P. Tinworth, Hannah Lithgow, Lars Dittus et al. · ACS Chemical Biology · 2019 · 175 citations

Molecular Regulation, Molecular Biology, Reversible Binding Protacs +25

Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP

Henrik Johansson, Yi‐Chun Isabella Tsai, Ken G. M. Fantom et al. · Journal of the American Chemical Society · 2019 · 124 citations · Full text