Lars Dittus

PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding

Christopher P. Tinworth, Hannah Lithgow, Lars Dittus et al. · ACS Chemical Biology · 2019 · 175 citations

Molecular Regulation, Molecular Biology, Reversible Binding Protacs +25

Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition

Samuel E. Dalton, Lars Dittus, Daniel A. Thomas et al. · Journal of the American Chemical Society · 2017 · 112 citations

Drug Target, Molecular Biology, General Approach +23

A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level

Anna Rutkowska, Douglas W. Thomson, Johanna Vappiani et al. · ACS Chemical Biology · 2016 · 84 citations

Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors

Lars Dittus, Thilo Werner, Marcel Muelbaier et al. · ACS Chemical Biology · 2017 · 32 citations

Drug Target, Kinase Inhibitors, Covalent Kinase Inhibitors +21

Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines

Douglas W. Thomson, Anne J. Wagner, Marcus Bantscheff et al. · Journal of Medicinal Chemistry · 2017 · 30 citations · Full text

Drug Target, Novel Nicotinamide Isoster, Chemical Biology +18