Darren Goffin

Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses

Darren Goffin, Megan Allen, Le Zhang et al. · Nature Neuroscience · 2011 · 232 citations · Full text

Chromatin, Genome Instability, Dna Binding +12

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

I-Ting Judy Wang, Megan Allen, Darren Goffin et al. · Proceedings of the National Academy of Sciences · 2012 · 224 citations · Full text

Signal Transduction Pathways, Autism Spectrum Disorders, Event-related Potentials +17

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome

Brian S. Johnson, Ying-Tao Zhao, Maria Fasolino et al. · Nature Medicine · 2017 · 121 citations · Full text

Transcriptional Regulation, Functional Genomics, Developmental Biology +8

Cellular origins of auditory event-related potential deficits in Rett syndrome

Darren Goffin, Edward S. Brodkin, Julie A. Blendy et al. · Nature Neuroscience · 2014 · 77 citations · Full text

Auditory Processing, Developmental Biology, Neurophysiology +11

Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome–like phenotypes

Janine M. Lamonica, Deborah Y. Kwon, Darren Goffin et al. · Journal of Clinical Investigation · 2017 · 68 citations · Full text