Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function

Miriam E. Bocarsly, Maria Fasolino, Gary A. Kane, +5

Proceedings of the National Academy of Sciences

Brain FunctionPrefrontal CortexRat ModelNeuroinflammationObesity +14

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

Katie C. Coate, Jeeyeon Cha, Shristi Shrestha, +16

Cell Metabolism

Human PancreasPancreatic CancerTmprss2 AreImmunologyPathology +7

Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

Maria Fasolino, Gregory W. Schwartz, Abhijeet R. Patil, +45

Nature Metabolism

Type 1Signal TransductionSingle-cell Multi-omics AnalysisMedicineDiabetes +10

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome

Brian S. Johnson, Ying-Tao Zhao, Maria Fasolino, +9

Nature Medicine

Transcriptional RegulationFunctional GenomicsDevelopmental BiologySignal TransductionGenomic Mechanism +6

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques

Jelena Petrovic, Yeqiao Zhou, Maria Fasolino, +16

Molecular Cell

Systems BiologySignal TransductionHyperconnected 3DGene RegulationCellular Regulatory Mechanism +7

TooManyCells identifies and visualizes relationships of single-cell clades

Gregory W. Schwartz, Yeqiao Zhou, Jelena Petrovic, +6

Nature Methods

BiologyToomanycells IdentifiesUnicellular OrganismPhylogeneticsSingle Cell Sequencing +8

BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia

Weimin Kong, Alexander J. Dimitri, Wang Wenliang, +30

Journal of Clinical Investigation

Chronic Lymphocytic LeukemiaT-regulatory CellImmunologyImmunoeditingPathology +14

Exome-wide evaluation of rare coding variants using electronic health records identifies new gene–phenotype associations

Joseph Park, Anastasia Lucas, Xinyuan Zhang, +38

Nature Medicine

Genome-wide Association StudyExome-wide EvaluationNew Gene–phenotype AssociationsGeneticsBiostatistics +7

Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression

Maria Fasolino, Naomi Goldman, Wenliang Wang, +15

Immunity

ChromatinType 1Chromatin OrganizationGenetic DeterminantChromatin Structure +12

Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels

Wenliang Wang, Maria Fasolino, Benjamin Cattau, +7

Proceedings of the National Academy of Sciences