Keith Hoffmaster

SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

Leila Dardaei, Hui Qin Wang, Manrose Singh et al. · Nature Medicine · 2018 · 198 citations · Full text

Alk Inhibitors, Medicine, Pharmacology +8

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

Qing-Yin Wang, Simon M. Bushell, Min Qing et al. · Journal of Virology · 2011 · 162 citations

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide

Keith Hoffmaster, Ryan Z. Turncliff, Edward L. LeCluyse et al. · Pharmaceutical Research · 2004 · 153 citations

Model Opioid Peptide, Gastrointestinal Peptide Hormone, Biochemistry +9

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)

Atwood K. Cheung, Brian Hurley, Ryan Kerrigan et al. · Journal of Medicinal Chemistry · 2018 · 128 citations · Full text

Genetics, Molecular Biology, Cytoskeleton +16

Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

Aurelio Bonavia, Michael Franti, Erin P. Keaney et al. · Proceedings of the National Academy of Sciences · 2011 · 94 citations

Novel Therapeutic Interventions, Medicinal Chemistry, Respiratory Syncytial Virus +15