George Diamantidis

Acute γ-Secretase Inhibition Improves Contextual Fear Conditioning in the Tg2576 Mouse Model of Alzheimer's Disease

Thomas A. Comery, Robert Martone, Suzan Aschmies et al. · Journal of Neuroscience · 2005 · 212 citations · Full text

Acute Treatment, Neuropsychology, Affective Neuroscience +19

<i>N</i>-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2<i>E</i>)-<i>N</i>-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1<i>H</i>-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Stacy Remiszewski, Lidia Sambucetti, Kenneth W. Bair et al. · Journal of Medicinal Chemistry · 2003 · 129 citations · Full text

Pathology, Pharmacotherapy, Pharmaceutical Chemistry +17

Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Scott C. Mayer, Anthony F. Kreft, Boyd L. Harrison et al. · Journal of Medicinal Chemistry · 2008 · 109 citations · Full text

Stable Analogue 10, Alzheimer ’, Social Sciences +19

Novel pyrazolopyrimidines as highly potent B-Raf inhibitors

Martin J. Di Grandi, Dan M. Berger, Darrin W. Hopper et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 29 citations · Full text

Medicinal Chemistry, Medicine, Novel Pyrazolopyrimidines +7

Discovery of a novel series of Notch-sparing γ-secretase inhibitors

Anthony F. Kreft, Boyd L. Harrison, Suzan Aschmies et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 25 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Medicine +7