Tyler R. Simpson

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Berna C. Özdemir, Tsvetelina Pentcheva‐Hoang, Julienne L. Carstens et al. · Cancer Cell · 2014 · 2.6K citations

Medicine, Cell Biology, Oncology +15

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

Tyler R. Simpson, Fubin Li, Welby Montalvo-Ortiz et al. · The Journal of Experimental Medicine · 2013 · 1.5K citations

Medicine, Immunology, Oncology +17

Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

Sergio A. Quezada, Tyler R. Simpson, Karl S. Peggs et al. · The Journal of Experimental Medicine · 2010 · 887 citations · Full text

Life Sciences, Immunology, Oncology +17

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

Sergio A. Quezada, Karl S. Peggs, Tyler R. Simpson et al. · The Journal of Experimental Medicine · 2008 · 213 citations · Full text

Life Sciences, Immunology, Oncology +17

Innate Immune Activation and CD4+ T Cell Priming during Respiratory Fungal Infection

Amariliz Rivera, Grace Ro, Heather L. Van Epps et al. · Immunity · 2006 · 135 citations · Full text

Life Sciences, Immunology, Microbiology +16