Karl S. Peggs

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Nicholas McGranahan, Andrew J.S. Furness, Rachel Rosenthal et al. · Science · 2016 · 3.1K citations · Full text

Life Sciences, Immunology, Oncology +17

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Christopher Abbosh, Nicolai J. Birkbak, Gareth A. Wilson et al. · Nature · 2017 · 1.9K citations · Full text

Life Sciences, Molecular Biology, Oncology +13

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

Tyler R. Simpson, Fubin Li, Welby Montalvo-Ortiz et al. · The Journal of Experimental Medicine · 2013 · 1.5K citations

Medicine, Immunology, Oncology +17

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

Karl S. Peggs, Sergio A. Quezada, Cynthia A. Chambers et al. · The Journal of Experimental Medicine · 2009 · 950 citations · Full text

Medicine, Immunology, Oncology +17

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

Waseem Qasim, Hong Zhan, Sujith Samarasinghe et al. · Science Translational Medicine · 2017 · 888 citations · Full text

Life Sciences, Immunology, Oncology +17