Cytosolic RNA:DNA hybrids activate the <scp>cGAS</scp> –STING axis

Arun K. Mankan, Tobias Schmidt, Dhruv Chauhan, +7

The EMBO Journal

A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

Jonathan L. Schmid‐Burgk, Tobias Schmidt, Vera B. Kaiser, +2

Nature Biotechnology

Transcriptional RegulationLigation-independent Cloning TechniqueNatural SciencesGeneticsMolecular Biology +8

Functional IRF3 deficiency in a patient with herpes simplex encephalitis

Line Lykke Andersen, Nanna Mørk, Line S. Reinert, +15

The Journal of Experimental Medicine

Autoimmune DiseaseNeurovirologyPathogenesisImmunologyViral Pathogenesis +12

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

Jonathan L. Schmid‐Burgk, Klara Höning, Thomas S. Ebert, +1

Nature Communications

Warfarin and vitamin K compete for binding to Phe55 in human VKOR

Katrin J. Czogalla, Arijit Biswas, Klara Höning, +4

Nature Structural & Molecular Biology

Protein FunctionSignal TransductionHuman VkorBiochemistryMedicine +5

Cre-dependent DNA recombination activates a STING-dependent innate immune response

Geneviève Pépin, Jonathan Ferrand, Klara Höning, +7

Nucleic Acids Research

GeneticsInnate Immune SystemImmunologyMolecular BiologyInnate Immunity +16

GGCX mutations show different responses to vitamin K thereby determining the severity of the hemorrhagic phenotype in VKCFD1 patients

Suvoshree Ghosh, Katrin Kraus, Arijit Biswas, +9

Journal of Thrombosis and Haemostasis

VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites

Katrin J. Czogalla, Kerstin Liphardt, Klara Höning, +4

Blood Advances

Frequently used bioinformatics tools overestimate the damaging effect of allelic variants

Line Lykke Andersen, Ewa Terczyńska‐Dyla, Nanna Mørk, +7

Genes and Immunity

Genome-wide Association StudyGenetic AnalysisBioinformatics ToolsAllelic VariantFunctional Genomics +13