Jessica Ward

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

Michelle Pacholec, John E. Bleasdale, Boris A. Chrunyk et al. · Journal of Biological Chemistry · 2010 · 896 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice

Emily Cokorinos, Jake Delmore, Allan R. Reyes et al. · Cell Metabolism · 2017 · 266 citations · Full text

Life Sciences, Biochemistry, Physiology +13

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

Matthew F. Calabrese, Francis Rajamohan, Melissa S. Harris et al. · Structure · 2014 · 180 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

Ryan M. Esquejo, Christopher T. Salatto, Jake Delmore et al. · EBioMedicine · 2018 · 150 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1<i>H</i>-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Kimberly O. Cameron, Daniel W. Kung, Amit S. Kalgutkar et al. · Journal of Medicinal Chemistry · 2016 · 117 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15