Christopher T. Lemke

Author

Boehringer Ingelheim (Canada)ORCID

Also Known As

C.T. Lemke, Christopher Lemke, Christopher T Lemke, Christopher T. Lemke

Publications

1.3K

Citations

H-Index

Concepts

All Affiliations

Boehringer Ingelheim (Canada)Broad Institute Harvard University Dana-Farber Cancer Institute Nuvisan (Germany)

About

Christopher T. Lemke is an author at Boehringer Ingelheim (Canada) specializing in medicine, natural sciences, and biochemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	11	11	589
2	Natural Sciences	10	10	477
3	Biochemistry	9	9	472
4	Biomolecular Engineering	1	1	31
5	Cell Biology	1	1	164

Christopher T. Lemke

Publications

1.3K

Citations

H-Index

Page 1

	Year	Citations
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers Takahiro Ito, Michael J. Young, Ruitong Li, Nature Genetics Tumor BiologySignal TransductionDigenic DependenceMedicineCancer Genomics	2021	164
Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein Christopher T. Lemke, Steve Titolo, Uta von Schwedler, Journal of Virology	2012	124
Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes Louie Lamorte, Steve Titolo, Christopher T. Lemke, Antimicrobial Agents and Chemotherapy	2013	122
Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly Lee D. Fader, Richard C. Bethell, Pierre Bonneau, Bioorganic & Medicinal Chemistry Letters Combinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryNatural Sciences	2010	104
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase Colin W. Garvie, Xiaoyun Wu, Malvina Papanastasiou, Nature Communications	2021	86
Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex Jason J. Kwon, Behnoush Hajian, Yuemin Bian, Nature BiochemistryProtein AssemblyNatural SciencesProtein X-ray CrystallographyMolecular Biology	2022	82
Ligand Bioactive Conformation Plays a Critical Role in the Design of Drugs That Target the Hepatitis C Virus NS3 Protease Steven R. LaPlante, Herbert Nar, Christopher T. Lemke, Journal of Medicinal Chemistry Drug TargetMolecular BiologyAntiviral DrugChemical BiologyBioactive Conformation	2013	49
Novel Inhibitor Binding Site Discovery on HIV-1 Capsid N-Terminal Domain by NMR and X-ray Crystallography Nathalie Goudreau, Christopher T. Lemke, Anne‐Marie Faucher, ACS Chemical Biology X-ray CrystallographyMolecular BiologyF NmrAntiviral DrugChemical Biology	2013	49
Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335 Christopher T. Lemke, Nathalie Goudreau, Songping Zhao, Journal of Biological Chemistry Virus StructureBiochemistryProtein FoldingViral HepatitisNatural Sciences	2011	47
Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity Steven R. LaPlante, Pat Forgione, Colette Boucher, Journal of Medicinal Chemistry Molecular BiologyAntiviral DrugChemical BiologyMedicinal ChemistryAtropisomer Chirality	2013	44

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