Christopher T. Lemke

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers

Takahiro Ito, Michael J. Young, Ruitong Li et al. · Nature Genetics · 2021 · 164 citations

Tumor Biology, Signal Transduction, Digenic Dependence +11

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

Christopher T. Lemke, Steve Titolo, Uta von Schwedler et al. · Journal of Virology · 2012 · 124 citations · Full text

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

Louie Lamorte, Steve Titolo, Christopher T. Lemke et al. · Antimicrobial Agents and Chemotherapy · 2013 · 122 citations · Full text

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

Lee D. Fader, Richard C. Bethell, Pierre Bonneau et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 104 citations

Combinatorial Chemistry, Medicinal Chemistry, Heterocyclic +8

Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

Colin W. Garvie, Xiaoyun Wu, Malvina Papanastasiou et al. · Nature Communications · 2021 · 86 citations · Full text