Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin

Gary J. Fisher, Taihao Quan, Trupta Purohit, +6

American Journal Of Pathology

FibrosisAged Human SkinCutaneous BiologyPathologyDermal Structure +8

Solar Ultraviolet Irradiation Reduces Collagen in Photoaged Human Skin by Blocking Transforming Growth Factor-β Type II Receptor/Smad Signaling

Taihao Quan, Tianyuan He, Sewon Kang, +2

American Journal Of Pathology

Skin DevelopmentHuman GrowthCutaneous BiologyPhotocarcinogenesisWound Healing +7

c-Jun–dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid

Gary J. Fisher, Subhash C. Datta, ZengQuan Wang, +5

Journal of Clinical Investigation

Collagen BreakdownImmunologyCutaneous Procollagen TranscriptionC-jun–dependent InhibitionDermatology +17

Reduced Expression of Connective Tissue Growth Factor (CTGF/CCN2) Mediates Collagen Loss in Chronologically Aged Human Skin

Taihao Quan, Yuan Shao, Tianyuan He, +2

Journal of Investigative Dermatology

FibrosisCutaneous BiologyMediates Collagen LossWound HealingDermatology +4

Enhancing Structural Support of the Dermal Microenvironment Activates Fibroblasts, Endothelial Cells, and Keratinocytes in Aged Human Skin In Vivo

Taihao Quan, Frank Wang, Yuan Shao, +5

Journal of Investigative Dermatology

Tissue EngineeringRegenerative MedicineAged Human SkinAgingEndothelial Cells +10

Elevated Matrix Metalloproteinases and Collagen Fragmentation in Photodamaged Human Skin: Impact of Altered Extracellular Matrix Microenvironment on Dermal Fibroblast Function

Taihao Quan, E.Graham Little, Hehui Quan, +3

Journal of Investigative Dermatology

Tissue EngineeringCollagen FragmentationCutaneous BiologyPhotocarcinogenesisMatrix Metalloproteinases +8

Ultraviolet Irradiation Blocks Cellular Responses to Transforming Growth Factor-β by Down-regulating Its Type-II Receptor and Inducing Smad7

Taihao Quan, Tianyuan He, John J. Voorhees, +1

Journal of Biological Chemistry

Ultraviolet Irradiation Alters Transforming Growth Factor β/Smad Pathway in Human Skin In Vivo

Taihao Quan, TianYuan He, Sewon Kang, +2

Journal of Investigative Dermatology

Skin DevelopmentHuman GrowthCutaneous BiologyPhotocarcinogenesisWound Healing +5

Alterations in extracellular matrix composition during aging and photoaging of the skin

Maxwell C. McCabe, Ryan C. Hill, Ken Calderone, +5

Matrix Biology Plus

YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts

Zhaoping Qin, Wei Xia, Gary J. Fisher, +2

Cell Communication and Signaling