Chris M. Semko

Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors

G. Leslie Burnett, Yu Chi Yang, James B. Aggen et al. · Journal of Medicinal Chemistry · 2022 · 63 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors

Anh P. Truong, Danielle L. Aubele, Gary D. Probst et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Gary D. Probst, Danielle L. Aubele, Simeon Bowers et al. · Journal of Medicinal Chemistry · 2013 · 32 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II)

Xiaocong M. Ye, Andrei W. Konradi, Jenifer Smith et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 20 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Abstract 4878: RMC-4550, an allosteric inhibitor of SHP2: Synthesis, structure, and anti-tumor activity

Elena S. Koltun, Naing Aay, Andreas Buckl et al. · Cancer Research · 2018 · 17 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17