Calum MacLeod

Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue

David F. Lappin, Calum MacLeod, A. Kerr et al. · Clinical & Experimental Immunology · 2001 · 149 citations · Full text

Immune Regulation, Immunology, Pathology +17

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

Sue J. Sohn, Kathy Barrett, Anne van Abbema et al. · The Journal of Immunology · 2013 · 123 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +25

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

Emily J. Hanan, Marie-Gabrielle Braun, Robert A. Heald et al. · Journal of Medicinal Chemistry · 2022 · 119 citations · Full text

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model

Jun Liang, Anne van Abbema, Mercedesz Balázs et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 20 citations · Full text

Medicinal Chemistry, Vivo Psoriasis Model, Medicine +10

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

Lewis Gazzard, Karen Williams, Huifen Chen et al. · Journal of Medicinal Chemistry · 2015 · 18 citations · Full text

Ache Activity, Drug Target, Pharmacotherapy +16