Senolytic CAR T cells reverse senescence-associated pathologies

Corina Amor, Judith Feucht, Josef Leibold, +15

Nature

T-regulatory CellImmunologyCellular SenescenceAutoimmunityImmunotherapy +3

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

Marcus Ruscetti, Josef Leibold, Matthew J. Bott, +17

Science

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Marcus Ruscetti, John P. Morris, Riccardo Mezzadra, +17

Cell

Pancreatic CancerPancreas CancerCellular SenescenceMedicineCell Biology +4

Resistance to TRK inhibition mediated by convergent MAPK pathway activation

Emiliano Cocco, Alison M. Schram, Amanda Kulick, +26

Nature Medicine

Signal TransductionCell RegulationMolecular PathwaySignaling PathwayReceptor Tyrosine Kinase +7

SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer

Eiki Ichihara, David Westover, Catherine B. Meador, +10

Cancer Research

The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer

Andrew Chow, Fathema Uddin, Michael Liu, +38

Immunity

Cancer ImmunosurveillanceMedicineImmunologyImmune Checkpoint InhibitorEctonucleotidase Cd39 +6

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

Loretah Chibaya, Katherine C. Murphy, Kelly D. DeMarco, +18

Nature Cancer

Ezh2 InhibitionCancer ResearchPancreatic CancerMedicineImmunology +6

HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway

Alison Smith, Emanuela Ferraro, Anton Safonov, +12

Nature Communications

Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer

Stella Paffenholz, Camilla Salvagno, Yu-Jui Ho, +11

Proceedings of the National Academy of Sciences

ImmunologyImmunoeditingCancer BiologyTumor BiologyOvarian Aging +14

Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models

Marissa S. Mattar, Craig McCarthy, Amanda Kulick, +3

Frontiers in Oncology