Eiki Ichihara

AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Darren A.E. Cross, Susan Ashton, Serban Ghiorghiu et al. · Cancer Discovery · 2014 · 2.2K citations · Full text

Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models

Catherine A. Eberlein, Daniel Stetson, Aleksandra Markovets et al. · Cancer Research · 2015 · 293 citations · Full text

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer

Gorjan Hrustanovic, Victor Olivas, Evangelos Pazarentzos et al. · Nature Medicine · 2015 · 275 citations · Full text

Ras-mapk Dependence Underlies, Eml4-alk–positive Lung Cancer, Medicine +11

Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells

Kazuhiko Shien, Shinichi Toyooka, Hiromasa Yamamoto et al. · Cancer Research · 2013 · 270 citations · Full text

Pathology, Stem Cell Biology, Cancer Biology +22

A Phase II Study of Trastuzumab Emtansine in HER2-Positive Non–Small Cell Lung Cancer

Katsuyuki Hotta, Keisuke Aoe, Toshiyuki Kozuki et al. · Journal of Thoracic Oncology · 2017 · 169 citations · Full text

Medicine, Cancer Cell Biology, Pathology +8