Eiki Ichihara

AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Darren A.E. Cross, Susan Ashton, Serban Ghiorghiu et al. · Cancer Discovery · 2014 · 2.2K citations · Full text

Medicine, Oncology, Pharmacology +13

Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models

Catherine A. Eberlein, Daniel Stetson, Aleksandra Markovets et al. · Cancer Research · 2015 · 300 citations · Full text

Medicine, Oncology, Pharmacology +17

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer

Gorjan Hrustanovic, Victor Olivas, Evangelos Pazarentzos et al. · Nature Medicine · 2015 · 277 citations · Full text

Medicine, Cancer Biology, Oncology +16

Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells

Kazuhiko Shien, Shinichi Toyooka, Hiromasa Yamamoto et al. · Cancer Research · 2013 · 273 citations · Full text

Medicine, Oncology, Pharmacology +17

Immune evasion through mitochondrial transfer in the tumour microenvironment

Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi et al. · Nature · 2025 · 248 citations · Full text

Medicine, Cancer Biology, Immunology +16