Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor <i>BRAF</i> gene mutations but lack mutations in <i>KRAS, NRAS,</i> or <i>MEK1</i>

Kadoaki Ohashi, Lecia V. Sequist, Maria E. Arcila, +21

Proceedings of the National Academy of Sciences

Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells

Kazuhiko Shien, Shinichi Toyooka, Hiromasa Yamamoto, +13

Cancer Research

PathologyStem Cell BiologyCancer BiologyTumor BiologyCancer Cell Biology +20

Novel Germline Mutation in the Transmembrane Domain of HER2 in Familial Lung Adenocarcinomas

Hiromasa Yamamoto, Koichiro Higasa, Masakiyo Sakaguchi, +12

JNCI Journal of the National Cancer Institute

Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer

Norimitsu Tanaka, Shinichi Toyooka, Junichi Soh, +11

Lung Cancer

Frequent MethylationOncogenic RoleOncogenic AgentEpigenetic ChangePathology +8

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy

Kazuhiko Shien, Shinichi Toyooka, Kouichi Ichimura, +12

Lung Cancer

Prognostic ImpactMedicineInduction ChemoradiotherapyBronchial NeoplasmCancer Treatment +6

JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non–Small Cell Lung Cancer

Kazuhiko Shien, Vassiliki A. Papadimitrakopoulou, Dennis Ruder, +14

Molecular Cancer Therapeutics

Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in <i>EGFR</i> -Mutant Non–Small Cell Lung Cancer Cells

Kei Namba, Kazuhiko Shien, Yuta Takahashi, +10

Molecular Cancer Research

Acquisition of cancer stem cell‐like properties in non‐small cell lung cancer with acquired resistance to afatinib

Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, +10

Cancer Science

PathologyCancer BiologyTumor BiologyCancer Cell BiologyRadiation Oncology +14

Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR‐TKIs in non‐small cell lung cancer

Hiroki Sato, Hiromasa Yamamoto, Masakiyo Sakaguchi, +13

Cancer Science

The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis

Kota Araki, Rie Kinoshita, Nahoko Tomonobu, +18

Journal of Molecular Medicine

FibrosisAntifibrotic TherapyInflammatory Lung DiseaseIdiopathic Pulmonary FibrosisImmunology +8