Kazuhiko Shien

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor <i>BRAF</i> gene mutations but lack mutations in <i>KRAS, NRAS,</i> or <i>MEK1</i>

Kadoaki Ohashi, Lecia V. Sequist, Maria E. Arcila et al. · Proceedings of the National Academy of Sciences · 2012 · 434 citations · Full text

Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer Cells

Kazuhiko Shien, Shinichi Toyooka, Hiromasa Yamamoto et al. · Cancer Research · 2013 · 270 citations · Full text

Pathology, Stem Cell Biology, Cancer Biology +22

Novel Germline Mutation in the Transmembrane Domain of HER2 in Familial Lung Adenocarcinomas

Hiromasa Yamamoto, Koichiro Higasa, Masakiyo Sakaguchi et al. · JNCI Journal of the National Cancer Institute · 2013 · 115 citations · Full text

Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer

Norimitsu Tanaka, Shinichi Toyooka, Junichi Soh et al. · Lung Cancer · 2011 · 109 citations

Frequent Methylation, Oncogenic Role, Oncogenic Agent +10

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy

Kazuhiko Shien, Shinichi Toyooka, Kouichi Ichimura et al. · Lung Cancer · 2012 · 97 citations

Prognostic Impact, Medicine, Induction Chemoradiotherapy +8