Thomas T. Tibbitts

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Olivier De Henau, Matthew Rausch, David A. Winkler et al. · Nature · 2016 · 865 citations

Medicine, Cancer Biology, Oncology +14

Design, Synthesis, and Biological Evaluation of Hydroquinone Derivatives of 17-Amino-17-demethoxygeldanamycin as Potent, Water-Soluble Inhibitors of Hsp90

Jie Ge, Emmanuel Normant, James R. Porter et al. · Journal of Medicinal Chemistry · 2006 · 189 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate

Catherine A. Evans, Tao Liu, André Lescarbeau et al. · ACS Medicinal Chemistry Letters · 2016 · 151 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +11

Mutations at Positions 153 and 328 inEscherichia coliAlkaline Phosphatase Provide Insight Towards the Structure and Function of Mammalian and Yeast Alkaline Phosphatases

J.E. Murphy, Thomas T. Tibbitts, Evan R. Kantrowitz · Journal of Molecular Biology · 1995 · 93 citations

Life Sciences, Biochemistry, Molecular Biology +10

Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199)

Viralkumar Patel, Kumudha Balakrishnan, Mark Douglas et al. · Leukemia · 2016 · 67 citations · Full text

Medicine, Hematology, Oncology +6