Thomas T. Tibbitts - Concepedia

Concepedia

Author

Thomas T. Tibbitts

Infinity Pharmaceuticals (United States)ORCID

Also Known As

T Tibbitts, T. T. Tibbitts, T. Tibbitts, T.T. Tibbitts, Thomas T Tibbitts, Thomas T. Tibbitts, Thomas Tibbitts, Tim Tibbitts

28

Publications

1.6K

Citations

12

H-Index

56

Concepts

All Affiliations

Infinity Pharmaceuticals (United States)Boston College

TT

About

Thomas T. Tibbitts is an author at Infinity Pharmaceuticals (United States) specializing in medicine, pharmacology, and natural sciences.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	7	7	1.3K
2	Natural Sciences	4	4	340
3	Biochemistry	4	4	340
4	Engineering	3	3	72
5	Biomedical Engineering	1	1	10

Thomas T. Tibbitts

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13

Publications

1.6K

Citations

12

H-Index

	Year	Citations
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells Olivier De Henau, Matthew Rausch, David A. Winkler, Nature Hematological MalignancyBlockade TherapyImmunologyImmune Checkpoint InhibitorMyeloid Cells	2016	843
Design, Synthesis, and Biological Evaluation of Hydroquinone Derivatives of 17-Amino-17-demethoxygeldanamycin as Potent, Water-Soluble Inhibitors of Hsp90 Jie Ge, Emmanuel Normant, James R. Porter, Journal of Medicinal Chemistry Hydroquinone DerivativesMedicinal ChemistryWater-soluble InhibitorsBiochemistryMedicine	2006	189
Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate Catherine A. Evans, Tao Liu, André Lescarbeau, ACS Medicinal Chemistry Letters ImmunologyRobust Inhibition-γ InhibitorPharmacotherapyImmuno-oncology Clinical Candidate	2016	146
Mutations at Positions 153 and 328 inEscherichia coliAlkaline Phosphatase Provide Insight Towards the Structure and Function of Mammalian and Yeast Alkaline Phosphatases J.E. Murphy, Thomas T. Tibbitts, Evan R. Kantrowitz Journal of Molecular Biology Positions 153Cellular EnzymologyBiochemistryYeast Alkaline PhosphatasesNatural Sciences	1995	93
Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199) Viralkumar Patel, Kumudha Balakrishnan, Mark Douglas, Leukemia Hematological MalignancyLymphoid NeoplasiaOncologyAltered ExpressionMedicine	2016	66
Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model Maolin Yu, Mark W. Ledeboer, Matthew H. Daniels, ACS Medicinal Chemistry Letters	2019	58
Diffraction diagnosis of protein folding in gap junction connexons Thomas T. Tibbitts, D. L. D. Caspar, W. C. Phillips, Biophysical Journal	1990	48
Kinetic and Structural Consequences of Replacing the Aspartate Bridge by Asparagine in the Catalytic Metal Triad ofEscherichia coliAlkaline Phosphatase Thomas T. Tibbitts, J.E. Murphy, Evan R. Kantrowitz Journal of Molecular Biology EngineeringBiochemistryBioenergeticsBiocatalysisNatural Sciences	1996	37
Transplanted organoids empower human preclinical assessment of drug candidate for the clinic Amy Westerling-Bui, Eva M. Fast, Thomas W. Soare, Science Advances EngineeringSolid Organ TransplantationImmunologyInvestigational New DrugPharmacodynamic Modeling	2022	25
<i>Escherichia coli</i> alkaline phosphatase: X‐ray structural studies of a mutant enzyme (His‐412 → Asn) at one of the catalytically important zinc binding sites Lan Ma, Thomas T. Tibbitts, Evan R. Kantrowitz Protein Science Cellular EnzymologyBiochemistryNatural SciencesEnzyme CatalysisMetalloprotein	1995	21

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