Emmanuel Normant

Carboxypeptidase E Is a Regulated Secretory Pathway Sorting Receptor: Genetic Obliteration Leads to Endocrine Disorders in Cpefat Mice

David R. Cool, Emmanuel Normant, Fusheng Shen et al. · Cell · 1997 · 454 citations

Cpefat Mice, Molecular Physiology, Signal Transduction +11

Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors

Thomas De Raedt, Zandra E. Walton, Jessica L. Yecies et al. · Cancer Cell · 2011 · 257 citations · Full text

Tumor Biology, Cancer Cell Vulnerabilities, Medicine +12

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90

Jens Sydor, Emmanuel Normant, Christine Pien et al. · Proceedings of the National Academy of Sciences · 2006 · 226 citations · Full text

Tumor Biology, Medicinal Chemistry, Medicine +13

Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials

Brian K. Albrecht, Victor Gehling, Michael C. Hewitt et al. · Journal of Medicinal Chemistry · 2016 · 214 citations · Full text

Immunology, Pharmacotherapy, Tumor Biology +22

Identification of (<i>R</i>)-<i>N</i>-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1<i>H</i>-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas

Rishi G. Vaswani, Victor Gehling, Les A. Dakin et al. · Journal of Medicinal Chemistry · 2016 · 214 citations · Full text