D.J. Marcotte

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

D.J. Marcotte, Weike Zeng, Jean‐Christophe Hus et al. · Bioorganic & Medicinal Chemistry · 2013 · 233 citations · Full text

Proteinlipid Interaction, Keap1 Kelch, Signal Transduction +12

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

D.J. Marcotte, Yuting Liu, Robert M. Arduini et al. · Protein Science · 2010 · 148 citations · Full text

Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol

Eric R. Goedken, M.A. Argiriadi, David Banach et al. · Journal of Biological Chemistry · 2015 · 96 citations · Full text

Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators

Bin Ma, Brian S. Lucas, Andrew G. Capacci et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 42 citations · Full text

Medicine, Chemistry, Pharmacology +3

Discovery of biaryl carboxylamides as potent RORγ inverse agonists

Jianhua Chao, Istvan Enyedy, Kurt van Vloten et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 37 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Medicine +5