Patrick Maloney

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

Bryan Goodwin, Stacey A. Jones, Roger R. Price et al. · Molecular Cell · 2000 · 1.9K citations · Full text

Signal Transduction, Biochemistry, Biliary Tract +10

6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

Roberto Pellicciari, Stefano Fiorucci, Emidio Camaioni et al. · Journal of Medicinal Chemistry · 2002 · 722 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Selective Fxr Agonist +14

Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR

Patrick Maloney, Derek J. Parks, Curt D. Haffner et al. · Journal of Medicinal Chemistry · 2000 · 521 citations · Full text

Altmetric Attention Score, Molecular Biology, Research Triangle Park +19

Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity

Marcos L. Sznaidman, Curt D. Haffner, Patrick Maloney et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 311 citations · Full text

Biological Activity, Molecular Pharmacology, Biochemistry +11

β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

Lauren M. Slosky, Yushi Bai, Krisztián Tóth et al. · Cell · 2020 · 140 citations · Full text

Molecular Pharmacology, Psychoactive Drug, Functional Selectivity +10