Martin J. Drysdale

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Suzanne A. Eccles, Andy Massey, Florence I. Raynaud et al. · Cancer Research · 2008 · 469 citations

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

Paul A. Brough, Wynne Aherne, Xavier Barril et al. · Journal of Medicinal Chemistry · 2007 · 442 citations · Full text

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

Andrew J. Massey, D.S. Williamson, Helen Browne et al. · Cancer Chemotherapy and Pharmacology · 2009 · 327 citations · Full text

Medicine, Apoptosis, Cell Death +7

Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms

Lisa Wright, Xavier Barril, Brian Dymock et al. · Chemistry & Biology · 2004 · 265 citations · Full text

Hsp90 Isoforms, Signal Transduction, Biochemistry +5

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

Brian Dymock, Xavier Barril, Paul A. Brough et al. · Journal of Medicinal Chemistry · 2005 · 231 citations · Full text

Crystal Structure, Drug Target, Molecular Biology +18