Michele Dowless

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

Jeremy R. Graff, Bruce W. Konicek, Thomas M. Vincent et al. · Journal of Clinical Investigation · 2007 · 375 citations · Full text

Tumor Biology, Therapeutic Suppression, Medicine +12

Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

Xueqian Gong, Lacey M. Litchfield, Yue Webster et al. · Cancer Cell · 2017 · 224 citations · Full text

Cdk6 Inhibitor Abemaciclib, Signal Transduction, Signaling Pathway +10

Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the <i>RB1</i> Tumor Suppressor Gene

Xueqian Gong, Jian Du, Stephen H. Parsons et al. · Cancer Discovery · 2018 · 220 citations

eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival

Jeremy R. Graff, Bruce W. Konicek, Rebecca L. Lynch et al. · Cancer Research · 2009 · 197 citations

Eif4e Activation, Urology, Genitourinary Cancer +11

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

Bruce W. Konicek, Jennifer R. Stephens, Ann M. McNulty et al. · Cancer Research · 2011 · 187 citations · Full text

Bioavailable Mnk Inhibitor, Cancer Biology, Tumor Biology +21