Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

Jeremy R. Graff, Bruce W. Konicek, Thomas M. Vincent, +24

Journal of Clinical Investigation

Tumor BiologyTherapeutic SuppressionMedicineTumor GrowthEif4e Mrna +10

Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

Xueqian Gong, Lacey M. Litchfield, Yue Webster, +27

Cancer Cell

Cdk6 Inhibitor AbemaciclibSignal TransductionSignaling PathwayGenomic AberrationsCell Regulation +8

Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the <i>RB1</i> Tumor Suppressor Gene

Xueqian Gong, Jian Du, Stephen H. Parsons, +38

Cancer Discovery

eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival

Jeremy R. Graff, Bruce W. Konicek, Rebecca L. Lynch, +14

Cancer Research

Eif4e ActivationUrologyGenitourinary CancerReduced Patient SurvivalMedicine +9

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

Bruce W. Konicek, Jennifer R. Stephens, Ann M. McNulty, +14

Cancer Research

Bioavailable Mnk InhibitorCancer BiologyTumor BiologySignaling PathwayCell Regulation +19

Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models

Caitlin D. Lowery, Michele Dowless, Matthew Renschler, +21

Clinical Cancer Research

LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer

Eliza Vakana, Susan E. Pratt, Wayne Blosser, +10

Oncotarget

PathologyCancer BiologyTumor BiologyBrafmut MelanomaReceptor Tyrosine Kinase +14

The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma

Caitlin D. Lowery, Alle B. VanWye, Michele Dowless, +7

Clinical Cancer Research

A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells

Courtney M. Tate, Roberto Pallini, Lucia Ricci‐Vitiani, +10

Cell Death and Differentiation

GliomaMedicineGlioblastoma Stem-like CellsStem Cell ResearchCancer Biology +8

Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F

Liandong Ma, Joshua R. Clayton, Richard A. Walgren, +20

Blood Cancer Journal