Lacey M. Litchfield

The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade

David Schaer, Richard P. Beckmann, Jack Dempsey et al. · Cell Reports · 2018 · 418 citations · Full text

The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Seth A. Wander, Ofir Cohen, Xueqian Gong et al. · Cancer Discovery · 2020 · 399 citations · Full text

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

Xiaojing Liu, Iris L. Romero, Lacey M. Litchfield et al. · Cell Metabolism · 2016 · 237 citations · Full text

Central Carbon Metabolism, Mitochondrial Function, Biochemistry +13

Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

Xueqian Gong, Lacey M. Litchfield, Yue Webster et al. · Cancer Cell · 2017 · 224 citations · Full text

Cdk6 Inhibitor Abemaciclib, Signal Transduction, Signaling Pathway +10

Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models

Ernst Lengyel, Lacey M. Litchfield, Anirban Mitra et al. · American Journal of Obstetrics and Gynecology · 2014 · 133 citations · Full text

Medicine, Pharmacology, Gynecology +9