Delineating the role of cooperativity in the design of potent PROTACs for BTK

Adelajda Zorba, Chuong Nguyen, Yingrong Xu, +30

Proceedings of the National Academy of Sciences

EngineeringMolecular BiologyOrganic ChemistryChemistrySignaling Pathway +16

Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

Mark E. Flanagan, J. A. Abramite, Dennis P. Anderson, +22

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetThiol-reactive Covalent InhibitorsChemistryChemical Biology +15

Preparation, Gram-Negative Antibacterial Activity, and Hydrolytic Stability of Novel Siderophore-Conjugated Monocarbam Diols

Mark E. Flanagan, Steven J. Brickner, Manjinder S. Lall, +21

ACS Medicinal Chemistry Letters

Bioorganic ChemistryAntimicrobial ChemotherapyPharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +14

Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl-<scp>l</scp>-lysine as an amine nucleophile

Upendra P. Dahal, A. Gilbert, R. Scott Obach, +7

MedChemComm

Pharmaceutical ScienceDrug TargetCovalent Drug DesignPharmacotherapyChemistry +15

Pyridone-Conjugated Monobactam Antibiotics with Gram-Negative Activity

Matthew F. Brown, Mark J. Mitton‐Fry, Joel T. Arcari, +28

Journal of Medicinal Chemistry

AntibioticsCompound 17MedicineEscherichia ColiAntibacterial Agent +9

Palladium-Catalyzed Stereoselective Formation of α-<i>O</i>-Glycosides

Brandon P. Schuff, Gregory J. Mercer, Hien M. Nguyen

Organic Letters

Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism

Kay Ahn, Markus Boehm, Matthew F. Brown, +26

ACS Chemical Biology

Aldo-keto ReductaseGlucose ProductionFatty Liver DiseaseChemical BiologySerine Hydrolase +18

Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections

Mark J. Mitton‐Fry, Joel T. Arcari, Matthew F. Brown, +30

Bioorganic & Medicinal Chemistry Letters

Gram-negative BacteriologySiderophore Uptake MechanismAntimicrobial SusceptibilityAntibioticsAntibacterial Agent +8

Automated solvent system screening for the preparative countercurrent chromatography of pharmaceutical discovery compounds

James Bradow, Frank Riley, Laurence Philippe, +3

Journal of Separation Science

Synthetic TetrazolePreparative ApplicationChemistrySolvent SystemMedicinal Chemistry +19