Keith L. Spencer

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

James F. Blake, Rui Xu, Josef R. Bencsik et al. · Journal of Medicinal Chemistry · 2012 · 184 citations · Full text

Human Tumors, Tumor Biology, Medicinal Chemistry +15

Enantioselective -Amino Acid Synthesis Based on Catalyzed Asymmetric Acyl Halide – Aldehyde Cyclocondensation Reactions

Scott G. Nelson, Keith L. Spencer · Angewandte Chemie International Edition · 2000 · 65 citations

Two-step Enantioselective Synthesis, Engineering, Biochemistry +13

3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6

Mark E. Fraley, Justin T. Steen, Edward J. Brnardic et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 46 citations · Full text

Medicinal Chemistry, Medicine, Drug Discovery +9

Discovery and SAR of spirochromane Akt inhibitors

Nicholas C. Kallan, Keith L. Spencer, James F. Blake et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 42 citations · Full text

Medicinal Chemistry, Medicine, Mechanism Of Action +6

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Josef R. Bencsik, Dengming Xiao, James F. Blake et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 37 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +8