Enantioselective -Amino Acid Synthesis Based on Catalyzed Asymmetric Acyl Halide – Aldehyde Cyclocondensation Reactions

Abstract

N-Protected β-amino acids are obtained from an operationally simple, two-step enantioselective synthesis, which integrates aluminum-catalyzed asymmetric acyl halide – aldehyde cyclocondensation reactions with amine-mediated SN2 ring opening of the derived enantiomerically enriched β-lactones (see scheme).